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Report on Carcinogens, Twelfth Edition; U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program, 2011

Known Carcinogens - Substances or groups of substances, occupational exposures associated with a technological process and medical treatments that are known to be carcinogenic (For the purpose of this list, “known carcinogens” are defined as agents with “sufficient evidence of carcinogenicity from studies in humans, which indicates a causal relationship between exposure to the agent, substance or mixture and human cancer.)

Tables below were taken from the American Cancer Society website at http://www.cancer.org

National Toxicology Program 12th Report on Carcinogens "Known to be human carcinogens"

  • Aflatoxins
  • Alcoholic beverage consumption
  • 4-Aminobiphenyl
  • Analgesic mixtures containing phenacetin
  • Aristolochic acids
  • Arsenic compounds, inorganic
  • Asbestos
  • Azathioprine
  • Benzene
  • Benzidine
  • Beryllium and beryllium compounds
  • 1,3-Butadiene
  • 1,4-Butanediol dimethylsulfonate (busulfan, Myleran®)
  • Cadmium and cadmium compounds
  • Chlorambucil
  • 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (MeCCNU)
  • bis(chloromethyl) ether and technical-grade chloromethyl methyl ether
  • Chromium hexavalent compounds
  • Coal tar pitches
  • Coal tars
  • Coke oven emissions
  • Cyclophosphamide
  • Cyclosporin A
  • Diethylstilbestrol (DES)
  • Dyes metabolized to benzidine
  • Environmental tobacco smoke
  • Erionite
  • Estrogens, steroidal
  • Ethylene oxide
  • Formaldehyde
  • Hepatitis B virus
  • Hepatitis C virus
  • Human papilloma viruses: some genital-mucosal types
  • Melphalan
  • Methoxsalen with ultraviolet A therapy (PUVA)
  • Mineral oils (untreated and mildly treated)
  • Mustard gas
  • 2-Naphthylamine
  • Neutrons
  • Nickel compounds
  • Oral tobacco products
  • Radon
  • Silica, crystalline (respirable size)
  • Solar radiation
  • Soots
  • Strong inorganic acid mists containing sulfuric acid
  • Sunlamps or sunbeds, exposure to
  • Tamoxifen
  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD); "dioxin"
  • Thiotepa
  • Thorium dioxide
  • obacco smoking
  • Vinyl chloride
  • Ultraviolet radiation, broad spectrum UV radiation
  • Wood dust
  • X-radiation and gamma radiation

Probable Carcinogens -Substances or groups of substances and medical treatments which may reasonably be anticipated to be carcinogens.

For the purpose of this report, substances “which may reasonable be anticipated to be carcinogens” are defined as those agents with:

  • Limited evidence of carcinogenicity from studies in humans, which indicates that causal interpretation is credible, but that alternative explanations, such as chance, bias or confounding factors, could not adequately be excluded,” or
  • Sufficient evidence of carcinogenicity from studies in experimental animals, which indicates there is an increased incidence of malignant and/or a combination of malignant and benign tumors (1) in multiple species or at multiple tissue sites or (2) by multiple routes of exposure or (3) to an unusual degree with regard to incidence, site or type of tumor or age at onset or
  • Less than sufficient evidence of carcinogenicity in humans or laboratory animals; however, the agent, substance or mixture belongs to a well-defined, structurally related class of substances whose members are listed in a previous Report on Carcinogens as either known to be a human carcinogen or reasonably anticipated to be a human carcinogen or there is convincing relevant information that the agent acts through mechanisms indicating it would likely cause cancer in humans.

"Reasonably anticipated to be human carcinogens"

  • Acetaldehyde
  • 2-Acetylaminofluorene
  • Acrylamide
  • Acrylonitrile
  • Adriamycin® (doxorubicin hydrochloride)
  • 2-Aminoanthraquinone
  • o-Aminoazotoluene
  • 1-Amino-2,4-dibromoanthraquinone
  • 1-Amino-2-methylanthraquinone
  • 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ)
  • 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)
  • 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ)
  • 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
  • Amitrole
  • o-Anisidine hydrochloride
  • Azacitidine (5-Azacytidine®, 5-AzaC)
  • Benz[a]anthracene
  • Benzo[b]fluoranthene
  • Benzo[j]fluoranthene
  • Benzo[k]fluoranthene
  • Benzo[a]pyrene
  • Benzotrichloride
  • Bromodichloromethane
  • 2, 2-bis-(bromoethyl)-1,3-propanediol (technical grade)
  • Butylated hydroxyanisole (BHA)
  • Captafol
  • Carbon tetrachloride
  • Ceramic fibers (respirable size)
  • Chloramphenicol
  • Chlorendic acid
  • Chlorinated paraffins (C12, 60% chlorine)
  • 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
  • Bis(chloroethyl) nitrosourea
  • Chloroform
  • 3-Chloro-2-methylpropene
  • 4-Chloro-o-phenylenediamine
  • Chloroprene
  • p-Chloro-o-toluidine and p-chloro-o-toluidine hydrochloride
  • Chlorozotocin
  • C.I. basic red 9 monohydrochloride
  • Cisplatin
  • Cobalt sulfate
  • Cobalt-tungsten carbide: powders and hard metals
  • p-Cresidine
  • Cupferron
  • Dacarbazine
  • Danthron (1,8-dihydroxyanthraquinone)
  • 2,4-Diaminoanisole sulfate
  • 2,4-Diaminotoluene
  • Diazoaminobenzene
  • Dibenz[a,h]acridine
  • Dibenz[a,j]acridine
  • Dibenz[a,h]anthracene
  • 7H-Dibenzo[c,g]carbazole
  • Dibenzo[a,e]pyrene
  • Dibenzo[a,h]pyrene
  • Dibenzo[a,i]pyrene
  • Dibenzo[a,l]pyrene
  • 1,2-Dibromo-3-chloropropane
  • 1,2-Dibromoethane (ethylene dibromide)
  • 2,3-Dibromo-1-propanol
  • Tris (2,3-dibromopropyl) phosphate
  • 1,4-Dichlorobenzene
  • 3,3'-Dichlorobenzidine and 3,3'-dichlorobenzidine dihydrochloride
  • Dichlorodiphenyltrichloroethane (DDT)
  • 1,2-Dichloroethane (ethylene dichloride)
  • Dichloromethane (methylene chloride)
  • 1,3-Dichloropropene (technical grade)
  • Diepoxybutane
  • Diesel exhaust particulates
  • Diethyl sulfate
  • Diglycidyl resorcinol ether
  • 3,3'-Dimethoxybenzidine
  • 4-Dimethylaminoazobenzene
  • 3,3'-Dimethylbenzidine
  • Dimethylcarbamoyl chloride
  • 1,1-Dimethylhydrazine
  • Dimethyl sulfate
  • Dimethylvinyl chloride 1,6-Dinitropyrene
  • 1,8-Dinitropyrene
  • 1,4-Dioxane
  • Disperse blue 1
  • Dyes metabolized to 3,3'-dimethoxybenzidine
  • Dyes metabolized to 3,3'-dimethylbenzidine
  • Epichlorohydrin
  • Ethylene thiourea
  • Di(2-ethylhexyl) phthalate
  • Ethyl methanesulfonate
  • Furan
  • Glass wool fibers (inhalable)
  • Glycidol
  • Hexachlorobenzene
  • Hexachlorocyclohexane isomers
  • Hexachloroethane
  • Hexamethylphosphoramide
  • Hydrazine and hydrazine sulfate
  • Hydrazobenzene
  • Indeno[1,2,3-cd]pyrene
  • Iron dextran complex
  • Isoprene
  • Kepone® (chlordecone)
  • Lead and lead compounds
  • Lindane and other hexachlorocyclohexane isomers
  • 2-Methylaziridine (propylenimine)
  • 5-Methylchrysene
  • 4,4'-Methylenebis(2-chloroaniline)
  • 4-4'-Methylenebis(N,N-dimethyl)benzenamine
  • 4,4'-Methylenedianiline and its dihydrochloride salt
  • Methyleugenol
  • Methyl methanesulfonate
  • N-methyl-N'-nitro-N-nitrosoguanidine
  • Metronidazole
  • Michler's ketone [4,4'-(dimethylamino) benzophenone]
  • Mirex
  • Naphthalene
  • Nickel (metallic)
  • Nitrilotriacetic acid
  • o-Nitroanisole
  • Nitrobenzene
  • 6-Nitrochrysene
  • Nitrofen (2,4-dichlorophenyl-p-nitrophenyl ether)
  • Nitrogen mustard hydrochloride
  • Nitromethane
  • 2-Nitropropane
  • 1-Nitropyrene
  • 4-Nitropyrene
  • N-nitrosodi-n-butylamine
  • N-nitrosodiethanolamine
  • N-nitrosodiethylamine
  • N-nitrosodimethylamine
  • N-nitrosodi-n-propylamine
  • N-nitroso-N-ethylurea
  • 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone
  • N-nitroso-N-methylurea
  • N-nitrosomethylvinylamine
  • N-nitrosomorpholine
  • N-nitrosonornicotine
  • N-nitrosopiperidine
  • N-nitrosopyrrolidine
  • N-nitrososarcosine
  • o-Nitrotoluene
  • Norethisterone
  • Ochratoxin A
  • 4,4'-Oxydianiline
  • Oxymetholone
  • Phenacetin
  • Phenazopyridine hydrochloride
  • Phenolphthalein
  • Phenoxybenzamine hydrochloride
  • Phenytoin
  • Polybrominated biphenyls (PBBs)
  • Polychlorinated biphenyls (PCBs)
  • Polycyclic aromatic hydrocarbons (PAHs)
  • Procarbazine hydrochloride
  • Progesterone
  • 1,3-Propane sultone
  • beta-Propiolactone
  • Propylene oxide
  • Propylthiouracil
  • Reserpine
  • Riddelliine
  • Safrole
  • Selenium sulfide
  • Streptozotocin
  • Styrene
  • Styrene-7,8-oxide
  • Sulfallate
  • Tetrachloroethylene (perchloroethylene)
  • Tetrafluoroethylene
  • Tetranitromethane
  • Thioacetamide
  • 4,4'-Thiodianaline
  • Thiourea
  • Toluene diisocyanate
  • o-Toluidine and o-toluidine hydrochloride
  • Toxaphene
  • Trichloroethylene
  • 2,4,6-Trichlorophenol
  • 1,2,3-Trichloropropane
  • Ultraviolet A radiation
  • Ultraviolet B radiation
  • Ultraviolet C radiation
  • Urethane
  • Vinyl bromide
  • 4-Vinyl-1-cyclohexene diepoxide
  • Vinyl fluoride

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